Abstract
This study aimed to develop a straightforward, sensitive, exact, quick, and accurate reverse phase high performance liquid chromatography (RP-HPLC) method for figuring out how much lisinopril is in pharmaceutical gels and other large amounts of medication. Agilent Zorbax Bonus-RP column (250 x 4.6 mm, 5μ) was used for the chromatographic separation. “A mobile phase composed of methanol and trifluoroacetic acid (50:50 v/v) was used to develop the analytical procedure. The flow was found to be occurring at a rate of 1-mL/min and with a wavelength of 215 nm. The retention time was 2.28 min. In a concentration range from 3–7 μg/mL (r2=0.998), the drug’s response was determined to be linear. The LoQ was 1.11 μg/mL, while the LoD was 0.36 μg/mL. Lisinopril’s %assay was determined to be 98.22%, while assays for the other medicines in the commercial formulation showed no interference from the excipients. This method functions well and can be applied to routine analysis.
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