Abstract
Abstract An HPLC/electro-chemical method with an internal standard was developed for the analysis of arteether in fat and muscle tissue giving good recovery and accuracy with moderate precision. Following an intravenous administration of arteether (11.6 mg/Kg in a micro-emulsion), it was found that after 15 minutes the arteether concentration was 18.4 ± 13.1 μg/g (15.8% of administered dose) in fat and 1.35 ± 0.25 μg/g (5.8% of dose) was found in muscle tissue. The concentration of arteether in fat tissue initially dropped very rapidly (t1/2 = 14 min), followed by a much slower rate of elimination (t1/2 = 34 hr). Using the same dose, vehicle, and route of administration, arteether had been reported to be cleared from plasma at a higher rate (t1/2 = 10 min).
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