Abstract
High performance liquid chromatographic methods have been developed for the assays of idarubicin-etoposide and idarubicinondansetron mixtures in 0.9% sodium chloride injection USP. The separation and quantitation of the idarubicin-etoposide mixture was achieved on an octylsilane column at ambient temperature using a mobile phase of 73:27 v/v 0.02 M aqueous monobasic sodium phosphate - acetonitrile at a flow rate of 1.0 mL/min with UV detection at 254 nm. The separation was achieved within 13 min. The method showed linearity for idarubicin hydrochloride and etoposide in the 2–32 and 10 – 160 μg/L ranges, respectively. Accuracy and precision were in the 0.1 – 2.9% and 0.1 – 2.1% ranges, respectively, for both analytes.
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