Abstract
The current study was intended to explore the phytochemical profiling and therapeutic activities of Putranjiva roxburghii Wall. Crude extracts of different plant parts were subjected to the determination of antioxidant, antimicrobial, antidiabetic, cytotoxic, and protein kinase inhibitory potential by using solvents of varying polarity ranges. Maximum phenolic content was notified in distilled water extracts of the stem (DW-S) and leaf (DW-L) while the highest flavonoid content was obtained in ethyl acetate leaf (EA-L) extract. HPLC-DAD analysis confirmed the presence of various polyphenols, quantified in the range of 0.02 ± 0.36 to 2.05 ± 0.18 μg/mg extract. Maximum DPPH scavenging activity was expressed by methanolic extract of the stem (MeOH-S). The highest antioxidant capacity and reducing power was shown by MeOH-S and leaf methanolic extract (MeOH-L), respectively. Proficient antibacterial activity was shown by EA-L extract against Bacillus subtilis and Escherichia coli. Remarkable α-amylase and α-glucosidase inhibition potential was expressed by ethyl acetate fruit (EA-F) and n-Hexane leaf (nH-L) extracts, respectively. In case of brine shrimp lethality assay, 41.67% of the extracts (LC50 < 50 µg/mL) were considered as extremely cytotoxic. The test extracts also showed mild antifungal and protein kinase inhibition activities. The present study explores the therapeutic potential of P. roxburghii and calls for subsequent studies to isolate new bioactive leads through bioactivity-guided isolation.
Highlights
The results demonstrated that distilled water (DW) and MeOH extracts of leaf possess maximum extraction efficiency, i.e., 6.3 ± 0.4%
Reducing power of P. roxburghii stem part was previously investigated; the current study revealed that leaf part of this plant possesses better antioxidant potential [12]
In case of leaf part DW and MeOH extracts were highly active whereas ethyl acetate (EA) and nH extracts showed some biological activities
Summary
Plants are nature’s gifts that have been employed for the management of various healththreatening diseases since the early ages [1,2,3]. Of the population across the globe depends upon plant-based therapeutics for healthcare needs [3]. Phytoconstituents are the compounds generated by plants as a defense system against pathogens and predators. They possess certain characteristics that are helpful for the treatment of diseases including antimicrobial, antioxidant, and stimulation as well as inhibition enzymes [4]. Plants contain a wide range of constituents such as alkaloids, tannins, polyphenolics, terpenoids, etc. Which are attributable to therapeutic potential [5] Plants contain a wide range of constituents such as alkaloids, tannins, polyphenolics, terpenoids, etc. which are attributable to therapeutic potential [5]
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