Abstract
Drugs acting on GABAA receptors are effective for the treatment of anxiety, sleep disorders, insomnia and convulsive disorders. For pharmacological studies on these ionotropic receptors we have recently developed a method for 'concentration jump' applications of neurotransmitters (or drugs) during two-microelectrode voltage-clamp experiments on Xenopus oocytes [1]. Automation, fast perfusion rates, and economical use of compounds make the system suitable for screening studies on ligand-gated ion channels.
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