Abstract
Objective: The aim of our study was to establish the content of some primary metabolites, such as amino acids in Crambe cordifolia and Crambe koktebelica. The lack of experimental data induced us to determine these compounds.
 Methods: Crambe cordifolia and Crambe koktebelica leaves were selected as the objects of the study. The amino acids in the raw materials were determined by the HPLC method.
 Results: The results of the research revealed that the leaves of Crambe cordifolia and Crambe koktebelica contain fifteen and sixteen free amino acids respectively. Among the free amino acids L-histidine was presented in Crambe cordifolia leaves in the greatest amount, its content was 12.19 µg/mg. The content of free L-arginine, L-valine, L-phenylalanine, L-isoleucine was the greatest in Crambe koktebelica leaves, it was 2.23 µg/mg, 2.04 µg/mg, 1.74 µg/mg, 1.50 µg/mg respectively. The content of bound L-glutamic acid, Glycine, L-arginine, L-leucine was the highest in Crambe cordifolia and Crambe koktebelica leaves.
 Conclusion: The results of the study showed that Crambe cordifolia and Crambe koktebelica can be considered as a source of highly digestible amino acids that can be used to treat some diseases.
Highlights
Medicinal plants are the major natural resources found in the world, in which it contains more active phytoconstituents [1]
The HPLC method identified in Crambe cordifolia and Crambe koktebelica leaves fifteen and sixteen free amino acids respectively
L-histidine was presented in Crambe cordifolia leaves in the greatest amount among the free amino acids, its content was 12.19 μg/mg
Summary
Medicinal plants are the major natural resources found in the world, in which it contains more active phytoconstituents [1]. Plants are recognized as a form of folk remedies due to their wide therapeutic potential and, in turn, minor side effects and good toleration with patients regardless of age [2,3,4]. The use for the benefit of mankind of medicinal plants (MP) in folk and scientific medicine has a centuriesold tradition [5, 6]. Medicinal plants play a main role in the development of traditional medicine, as well as actual pharmaceuticals [7,8,9]. Since 1981, 38 molecules have been derived from medicinal plants, out of which 1,130 new therapeutic agents have approved as pharmaceutical drugs [10]. Herbal remedies are widely used in the complex treatment of various diseases [11]
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