实验鼠的母婴分离操作及对HPA轴的影响

Abstract

文章对实验鼠母婴分离操作的主要形式进行了描述，主要包括早期处置和母爱分离；并根据分离操作的主要特点，如分离频率和幼鼠是否单独分离，对实验鼠母爱分离的方式做了进一步的分类，包括母爱剥夺，重复母爱分离和非重复母爱分离；以及母爱分离和早期剥夺。最后文章简要探讨了早起处置和母爱分离对压力应对的主要机制——下丘脑–垂体–肾上腺轴的影响。 The paper described different operations of mother-pup separation, including early handling and maternal separation. Maternal separation was further categorized into maternal deprivation, daily maternal separation and occasional maternal separation; it was also categorized into maternal separation and early deprivation. Finally, a brief summary of the effects of mother-pup separation on HPA axis activity was also provided.