Abstract
Results:Both inHCsand inMDDs,800hand2300hbasal PRL (BL PRL) andTRH-PRL responses (i.e. PRL)werehigher inwomen than inmen (all p<0.05). 2300hPRL and PRL (difference between 2300h and 800hPRL) were lower in drug-free female MDDs compared to female HCs (all p<0.02). In women only, 2300h-BL PRL and PRL (at 800h and 2300h) levels were higher after two weeks of ADT than at baseline (all p<0.005). These changes did not differ across the antidepressant drugs andwere not associatedwith clinical response. Conclusion: Our results confirm marked sex difference in PRL secretion among controls and patients. Blunted 2300hPRL and PRL values at baseline support an alteration of TRH receptor circadian chronesthesy in depressedwomen. After 2 weeks of ADT, changes in PRL levels in women suggest that different types of ADT could enhance TRH—and/or serotonin—transmission regardless of clinical outcome.
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