Abstract
To present our experience and results with the use of collagenase of the Clostridium Histolyticum (Xiapex®) plus manual modeling and a penile traction device (PTD) in the treatment of Peyronie’s Disease (PD). We prospectively collected all patients diagnosed with PD and treated with this combination therapy in two healthcare centres. Inclusion criteria were: age >18, informed consent given, palpable plaque, curvature >30º, adequate previous manipulation of a PTD, and important disturbance of sexual intercourse. We excluded patients with severe calcification of the plaque. We collected all demographic data, IIEF-5 and PDQ scores, comorbidities, time since onset of symptoms, and assessed the curvature with a Kelami test. We offered the patients a maximum of 4 cycles, each one consisting on 2 injections in 24-72 hours time, and followed by 6 weeks of manual modelling and a minimum of 4 hours of daily use of a PTD. We stopped the protocol if no improvement was observed after the cycle, or continued it until the curvature was <30º or the patient managed with the residual one.
Published Version
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