HP-09-005 Sex hormone profile on hemodialysis

Abstract

Sexual dysfunction is one of the numerous consequences of chronic renal failure. The aim of this study is the search for the origin of these sexual disturbances, through the investigation of the hypothalamohypophysogonadic axis in kidney failure patients. We measured FSH, LH, testosterone, prolactin and TSH in male patients undergoing hemodialysis (patient group = 55 subjects) and in virile, fertile men from Gynecology department of Tahar Sfar hospital (control group = 55 subjects). The average age of patients was 48.2 ± 11.8 years and 47.89 ± 5.93 years in control group (p = 0.87). All patients were fertile and had a normal sexual activity before undergoing hemodialysis. Patients had low testosterone value (3.84 ± 1.77 ng/mL vs 5.41 ± 2.03 ng/mL; p = 0.004) compared to control group. The levels of FSH and LH were higher in patients undergoing hemodialysis (respectively8.83 ± 6.5 UI/L vs 4.31 ± 2.62 UI/L; p = 0.002 and14.62 ± 8.86 UI/L vs 6.43 ± 3.79 UI/L; p < 0.001). Even levels of prolactin were higher significantly among these patients (respectively 465.54 ± 299.66 mU/L vs 234.66 ± 131.68 mU/L; p = 0.007). However, no significant difference was noted between the 2 groups for the LH / FSH ratio (p = 0.36). Among the study, only 5 patients had serum thyroid stimulating hormone levels above the laboratory reference range (> 4.5 mIU/L) without any differences between subjects and patients group.