Abstract
To evaluate the severity of liver damage in NASH patients, by means of Transient Elastography (TE), using prespecified cut-off values of liver stiffness (LS) measurements. Our retrospective study included 478 NASH patients. Ten LS measurements were performed in each patient by means of TE (M-probe). A median value expressed in kPa was calculated. Reliable measurements were defined as: median value of 10 LS measurements with a success rate≥60% and an interquartile range interval<30%. Patients were divided using prespecified TE cut-offs for LS (Wong criteria, Hepatology 2010):<7.9kPa (F≥3 excluded); values ranging between 7.9-9.6 kPa ("gray zone"); and >9.6kPa (F≥3). Reliable measurements were obtained in 81.6% of NASH patients. The percentage of women, mean age and median BMI were significantly higher in patients with failed and unreliable vs. those with reliable measurements: 44.3% vs. 30.2%, p = 0.01, 51.2 ± 10.7 years vs. 45.4 ± 11.9 years, p < 0.0001 and 31.1 kg/m2 (17.6-41) vs. 28.7 kg/m2 (17.5-53.6),p = 0.0004 respectively. 390 patients with reliable LS measurements were included in the final analysis. Of those, 70.8% had no severe fibrosis, 10.8% were in the "gray zone" and 18.5% had severe fibrosis. Reliable LS measurements were obtained in 81.6% of NASH patients, using a standard M-probe. Approximately 30% of NASH patients had LS measurements compatible with severe fibrosis.
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