Abstract
How Traumatic Experiences Leave Their Signature on the Genome: An Overview of Epigenetic Pathways in PTSD.
Highlights
Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior
Three review articles describe the compelling evidence for epigenetic alterations, DNA methylation, as a consequence of exposure to stress encountered early in development
Use a rodent model of early-life adversity to explore the relationship between stress, genetic background, and sex in the determination of neurobehavioral and epigenetic outcomes. Data presented in these four articles are consistent with the notion that epigenetic programing early in life confers an enhanced risk on disease development upon re-exposure to trauma or stress
Summary
Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Two original research articles provide empirical support for DNA methylation as a useful biomarker, in the detection and diagnosis of PTSD, and as a biological measure for prediction of response to treatment, monitoring treatment efficacy, and prognosis of outcome. Three review articles describe the compelling evidence for epigenetic alterations, DNA methylation, as a consequence of exposure to stress encountered early in development.
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