Abstract

Recurrent pericarditis (RP) is one of the most common complications of pericarditis, affecting 15-30% of patients after an initial episode and >40% after a first recurrence.[1, 2] Up to 5-10% of RP patients develop multiple recurrences that are difficult to treat and refractory to conventional anti-inflammatory therapy, suggestive of refractory corticosteroid-dependent, colchicine-resistant RP.[2, 3] Several treatment options are suggested for such patients, including interleukin-1 (IL-1) antagonists, which are currently off-label for treating pericarditis in Canada.[1, 3] This paper aims to provide a focused guide to using anti-IL-1 agents (specifically anakinra and rilonacept), including practical tips from our experience.

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