How to train a neuron

Rui P Costa,P Jesper Sjöström,Alanna J Watt

doi:10.7554/elife.00491

Rui P Costa, P Jesper Sjöström + Show 1 more

Open Access

https://doi.org/10.7554/elife.00491

Copy DOI

Abstract

A cellular learning rule known as spike-timing-dependent plasticity can form, reshape and erase the response preferences of visual cortex neurons.

Highlights

A cellular learning rule known as spike-timing-dependent plasticity can form, reshape and erase the response preferences of visual cortex neurons
spike-timing-dependent plasticity (STDP) is attractive as a cellular learning rule (Markram et al, 2012), its biological relevance has been called into ques tion because most STDP experiments have been carried out in dissected brain tissue (Frégnac et al, 2010; Lisman and Spruston, 2010)
To assess the importance of STDP in the visual cortex, Pawlak, Kerr and co-workers used a visual stimulus to evoke a response in a neuron, and paired this repeatedly with a brief injection of current to elicit a spike (Figure 2A)

Summary

Introduction

A cellular learning rule known as spike-timing-dependent plasticity can form, reshape and erase the response preferences of visual cortex neurons. Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo. Image Visual cortex neurons alter their responses using spike-timing-dependent plasticity in vivo

Results

Conclusion