Abstract
Little is known about the effects of a microgravity environment in space on biological, chemical, and physical processes. It also remains unclear if it is possible to simulate a space microgravity environment or effect on Earth. This paper discusses, according to the mechanical/physical principles of the basic processes of cell growth in space, the issues of what gravitational change is, how a space microgravity environment or effect can be simulated, and how biological responses to a simulated microgravity environment can be mimicked. It aims to elucidate relevant concepts in space life science and biotechnology, as well as in space physiology and medicine, and to present the scientific merits of related ground-based investigations.
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