Abstract
A few years ago Todaro and Green1 developed a cell-culture line of mouse fibroblasts that exhibited an unusual degree of growth control. This line, called the 3T3 mouse line, consists of fibroblasts or fibroblast-like cells that grow as a monolayer. When the culture reaches a certain density and the cells are confluent or near confluent, cellular proliferation ceases almost completely. To be sure, this growth control is only relative since, by simply increasing the concentration of serum, these cells continue to proliferate and divide even after they have reached confluence.2 However, under constant culture conditions, constant frequency of medium changes . . .
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