Abstract
Cancer is cell fleeing from death by blocking the intrinsic and extrinsic pathways of cell death programs. In the present work, the experimental formula was designed to remove these blockers. It was applied on 120 Swiss albino mice which were inoculated intraperitoneally and subcutaneously with Ehrlich Ascites Carcinoma cells; 1 × (106) cell/mouse. The activity of the cell death programs of the tumor was detected by measuring the volume of Ascites fluid, counting the number of dead cancer cells, measuring the size of the tumor, detecting the positive reaction of caspase enzyme in cancer cells and presence of macrophages and apoptotic bodies in tumor tissue. The experimental formula succeeded in removing the blockers of the cell death program in cancer cells returning the cell death program to work again.
Highlights
Cancer is a serious problem; it is more dangerous than nuclear bombs [1]
The core of this paper is reactivating the death programs in cancer cells by inhibiting the activation of nuclear factor kappa-b (NF-kB), which is responsible for producing the six factors used by cell to shut down the intrinsic and extrinsic pathways of programs of cell death
Removing the Carcinogenic Substances out of Cancer Cells The Cell membrane consists of two layers of phospholipid; each layer is composed of lipids and phosphate groups
Summary
World Health Organization in 2015 reported that 8.8 million people around the world died from cancer. The NF-kB is responsible for the production of six elements (muc-1, muc-4, muc-16, Bcl, MMPs, and DcR3), which are used by cells to block the intrinsic and extrinsic programs of cell death, leading to carcinogenesis [8]. If such blockers for cell death were removed, apoptosis pathways would be activated and cancer cells would succumb to death. We adopted the following strategy to remove all blockers of death programs (intrinsic and extrinsic): removing the carcinogenic substances out of the cell, regulating the levels of detoxification phase-I enzymes, scavenging the free radicals especially oxygenate origin, as superoxide free radicals and hydrogen peroxide, and keeping the NF-kB in inactive forms. The present study aimed to stimulate the death programs of cancer cells to work again and cure cancer within a short period using plants extract
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
