Abstract
Disorders of CNS white matter (WM) include hereditary syndromes, metabolic diseases, infectious processes, conditions caused by toxic agents, demyelinating diseases, and nutritional deficiencies. WM disorders are characterized by long tract signs (e.g., hyperreflexia), ataxia (if cerebellar pathways are involved), and a notable absence of cortical signs (e.g., seizures, aphasia, or apraxia). Diseases of WM, such as multiple sclerosis and vitamin B12 deficiency, are known to have neurobehavioral …
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