Abstract
To assess the impact of using quality criteria for liver stiffness (LS) evaluation by means of 2D Shear Wave Elastography from General Electrics (2D-SWE.GE), while using Transient Elastography (TE) as reference. We included 226 subjects in our study, with or without chronic liver disease, in whom LS was assessed using 2D-SWE.GE (LOGIQ E9, GE Healthcare) and TE (FibroScan, EchoSens). Reliable LS measurements were defined for TE as the median value of 10 measurements with a success rate of ≥60% and an interquartile range (IQR)<30% of the median LS values. For 2D-SWE.GE 10 LS measurements were acquired in a homogenous area and the IQR and the IQR/M were calculated in each case. We divided our subjects into 3 groups according to the 2D-SWE.GE IQR/M: IQR/M<0.10: 41 (18.1%) cases; 0.10<IQR/M≤0.30: 155 (68.6%) cases; IQR/M>0.30: 30 (13.3%) cases. We calculated the correlation coefficient between TE and 2D-SWE.GE in each group. All 226 (100%) subjects included had 10 valid measurements by means of 2D-SWE.GE and reliable results by TE. A strong positive correlation was found between LS values obtained by means of 2D-SWE.GE and TE in the IQR/M<0.10 group (r=0.84, p<0.0001). A strong positive correlation was found between LS values obtained by means of 2D-SWE.GE and TE in the 0.10<IQR/M≤0.30 group (r=0.80, p<0.0001). A weak positive correlation was found between LS values obtained by means of 2D-SWE.GE and TE in the IQR/M>0.30 group (r=0.41, p=0.02). The correlations were significantly stronger in the IQR/M<0.10 and 0.10<IQR/M≤0.30 groups as compared to the IQR/M>0.30 group (both p=0.0013). No statistical differences were found between the correlations in the IQR/M<0.10 and 0.10< IQR/M≤0.30 groups (p=0.43). Using the IQR/M<0.30 as quality criteria significantly increase the reliability of LS measurements by means of 2D-SWE.GE. Using IQR/M<0.10 criteria does not significantly improve the reliability of 2D-SWE.GE LS measurements as compared to 0.10< IQR/M≤0.30 criteria.
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