Abstract
After endocytosis, endosomes fuse with one another. One targeting factor appears to be the production of phosphatidylinositol 3-phosphate in membranes; this lipid head group is then recognized by so-called FYVE domains found on some endosomal fusion proteins. Kutateladze and Overduin present an analysis of the structure of the FYVE domain of early endosome antigen 1 in complex with phosphatidylinositol 3-phosphate and suggest a mechanism by which these interactions may promote endosome recognition. For an excellent overview on how FYVE domains function in signaling, read the STKE perspective by Corvera . T. Kutateladze, M. Overduin, Structural mechanism of endosome docking by the FYVE domain. Science 291 , 1793-1796 (2001). [Abstract] [Full Text] S. Corvera, Signal transduction: Stuck with FYVE domains. Science's STKE (2000), http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2000/37/pe1 [Full Text]
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