How to face the low intrinsic sensitivity of 2D heteronuclear NMR with fast repetition techniques: go faster to go higher!

Abstract

Nuclear Magnetic Resonance (NMR) is one of the most widely used analytical techniques in numerous domains where molecules are objects of investigation. However, major limitations of multidimensional NMR experiments come from their low sensitivity and from the long times needed for their acquisition. In order to overcome such limitations, fast repetition NMR techniques allowed for the reduction of 2D experimental time and for the conversion of the gained time into a higher number of scans leading to a better sensitivity. Since 2012, Dr. Jonathan FARJON developed new NMR techniques based on fast-pulsing methods to compensate the inherent low sensitivity per unit of time of NMR. Thus, he was contributing for new advances in NMR especially with fast repetition 2D heteronuclear NMR techniques. New opportunities are highlighted with fast repetition techniques: the access to information on low abundant nuclei, the enhancement of the detection for low concentrated compounds and the probing of weak interactions like hydrogen bonds at natural abundance.