Abstract
Liver microcirculation plays an essential role in the progression and aggravation of chronic liver disease. Hepatic sinusoid environment, mainly composed by hepatocytes, liver sinusoidal endothelial cells, Kupffer cells, and hepatic stellate cells, intimately cooperate to maintain global liver function and specific phenotype of each cell type. However, continuous liver injury significantly deregulates liver cells protective phenotype, leading to parenchymal and non-parenchymal dysfunction. Recent data have enlightened the molecular processes that mediate hepatic microcirculatory injury, and consequently, opened the possibility to develop new therapeutic strategies to ameliorate liver circulation and viability. The present review summarizes the main cellular components of the hepatic sinusoid, to afterward focus on non-parenchymal cells phenotype deregulation due to chronic injury, in the specific clinical context of liver cirrhosis and derived portal hypertension. Finally, we herein detail new therapies developed at the bench-side with high potential to be translated to the bedside.
Highlights
Frontiers in MedicineLiver microcirculation plays an essential role in the progression and aggravation of chronic liver disease
CHRONIC LIVER DISEASE (CLD)Chronic liver disease is one of the most important causes of death worldwide representing 1.03 million deaths per year [1]
The present review summarizes the main cellular components of the hepatic sinusoid, to afterward focus on non-parenchymal cells phenotype deregulation due to chronic injury, in the specific clinical context of liver cirrhosis and derived portal hypertension
Summary
Liver microcirculation plays an essential role in the progression and aggravation of chronic liver disease. The present review summarizes the main cellular components of the hepatic sinusoid, to afterward focus on non-parenchymal cells phenotype deregulation due to chronic injury, in the specific clinical context of liver cirrhosis and derived portal hypertension. Sinusoidal Cells in Chronic Liver Disease research efforts mainly focus on developing effective therapeutic options to improve the phenotype of sinusoidal cells, which would lead to a global improvement of liver function. It will markedly reduce the probability of decompensation and improve overall survival [5].
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