Abstract
Nanoporous silica nanoparticles (NSNs) have been considered with great interest as drug delivery agents owing to their superior properties. Herein, we review typical and recent progresses of NSNs, and for the first time, systemically pointed out the relationship between their formation mechanism, structure and regulation of drug delivery. Along with intelligent strategies of molecular/supramolecular switches and lipid membrane, NSNs greatly benefits from combination with molecular/supramolecular units as switches or from wrapping lipid membrane on their outside layer, which greatly improves regulation of drug delivery and therefore exert better efficacy of anticancer and other effects of the nanocomposite. It is expected that the review shall be of significance in designing NSNs as drug delivery systems with high efficiency and quality.
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