Abstract
Novel Coronary Pneumonia is the most infectious disease with the highest number of morbidity and mortality in 100 years. Despite aggressive and effective COVID-19 prevention and control measures, countries have been unable to stop its outbreaks. With the widespread use of vaccines, the occurrence of COVID-19 has declined markedly. April 21, 2021, New York scholars reported Vaccine Breakthrough Infections with SARS-CoV-2 Variants, which immediately attracted widespread attention. In this mini-review, we focus on the characteristics of SARS-CoV-2 and its mutant strains and vaccine breakthrough infections. We have found that outbreaks of vaccine-breaking SARS-CoV-2 Delta infections in many countries are primarily the result of declining vaccine-generated antibody titers and relaxed outbreak management measures. For this reason, we believe that the main response to vaccine-breaking infections with the SARS-CoV-2 variant is to implement a rigorous outbreak defense policy and vaccine application. Only by intensifying the current vaccination intensity, gradually improving the vaccine and its application methods, and strengthening non-pharmaceutical measures such as travel restrictions, social distancing, masking and hand hygiene, can the COVID-19 outbreak be fully controlled at an early date.
Highlights
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a highly contagious virus that is spread primarily by droplets or close contact and is spreading faster, in bizarre ways, and in larger numbers than anyone in the world expected [1–3]
Two women aged over 50 years were identified among 417 people who had received a second dose of BNT162b2 (Pfizer Biotech) or mRNA-1273 (Modena) vaccine at least 2 weeks earlier Presence of vaccine breakthrough infection
Around a wedding outside Houston, Texas, two patients from India may have transmitted the delta-mutant virus to other guests, six of whom were fully vaccinated (Pfizer BNT162b2, Moderna mRNA-1273 and Covaxin BBV152)
Summary
Deal With Vaccine Breakthrough Infection With SARS-CoV-2 Variants. Ying Guo 1, Jun Meng 2, Caide Liu 3, Guosheng Chen 4, Yuhua Chi 3, Shiliang Zheng 3 and Haixia Wang 5*. April 21, 2021, New York scholars reported Vaccine Breakthrough Infections with SARS-CoV-2 Variants, which immediately attracted widespread attention. In this minireview, we focus on the characteristics of SARS-CoV-2 and its mutant strains and vaccine breakthrough infections. We have found that outbreaks of vaccine-breaking SARS-CoV-2 Delta infections in many countries are primarily the result of declining vaccine-generated antibody titers and relaxed outbreak management measures. For this reason, we believe that the main response to vaccine-breaking infections with the SARS-CoV-2 variant is to implement a rigorous outbreak defense policy and vaccine application.
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