HOW TESTOSTERONE THERAPY IS ADVANTAGEOUS IN IMPROVING THE ART OUTCOME IN POOR OVARIAN RESPONDERS UNDERGOING IVF-ICSI CYCLES

Abstract

This RCT aimed to determine whether pretreatment with testosterone improves the results in poor responders undergoing ART cycles. 68 poor responder patients of previous ART cycles were randomly divided into two groups, 34 patients treated with a placebo (lubricant gel, control group) and 34 patients treated with testosterone gel (Study group). Inclusion criteria were : poor responder patients for IVF-ICSI cycles, patients older than 35 years, IVF-ICSI cycle with previous poor response , AFC <5–7, AMH <0.5–1.1 ng/ml, Fertility outcomes were compared between two groups. The two groups were not statistically different in terms of FSH , AFC, AMH, The number of oocytes and embryos in the study (testosterone gel ) group were significantly higher than in the control group. The mean number of oocytes obtained was 3.26 ± 1.04 versus 1.24 ± 1.06 and embryos was 2.34 ± 0.28 versus 0.89 ± 0.32 . The clinical pregnancy rate was 17% ( 6/34) in the study (testosterone gel ) group ,were significantly higher versus than in the control group 06 % ( 2/34). According to the results of our study, the testosterone gel has a positive impact on fertility rate in patients with poor-ovarian-reserve.