How Taking into Account the Pyloric Tonus Contributes to Treatment Success While Administering Gastric "Botulinum Toxin A" for Weight Loss.

Abstract

To analyze how considering the structure of normotonic pylorus (NP) or hypotonic pylorus (HP) contributes to treatment success in patients administered gastric botulinum toxin A for weight loss. We measured body mass indexes (BMIs) of the patients who applied for gastric botulinum toxin A (BTA) for weight loss, before and 6months after the procedure. The patients' pylori were classified as normotonic pylorus (NP) if, during endoscopy, they had a normal peristaltic motion and was closing completely, and as hypotonic pylorus if they were not closing properly or were aperistaltic. We compared the patients' mean pre-operative and 6-month post-operative BMIs. The groups were compared using the chi-square test where a p˂0.05 was considered significant. The study included 178 patients administered gastric BTA. In the assessment made without considering the pyloric structure, the mean BMI decreased from 34.76 ± 7.65 to 33.09 ± 7.80kg/m2, while the difference was not statistically significant (p˂0.06). Conversely, in the analysis performed considering the structure of pylorus, the mean pre-operative BMI of the 45 patients with HP structure was 35.16 ± 7.07kg/m2 which decreased to 35.11 ± 7.03kg/m2 6months after the procedure; hence, the difference was not statistically significant (p˂0.7). The mean pre-operative BMI of the 133 patients with NP structure, 34.63 ± 7.84kg/m2, decreased to 32.40 ± 8.05kg/m2 6months after the procedure and the difference was statistically significant (p˂0.05)*. We advise to be selective in BTA administration and to administer BTA to the patients who, endoscopically, have a NP structure.