Abstract
Physiology Chronic sleep loss can have negative health effects, including weight gain and type 2 diabetes. Underlying molecular processes in key metabolic tissues are thought to be to blame. Cedernaes et al. compared molecular changes such as DNA methylation in fat and skeletal muscle tissue samples taken from 15 young Caucasian males after a night of sleep loss and after a normal night's sleep. The two tissue types responded very differently. In muscle, sleep loss enhanced skeletal muscle breakdown by down-regulating a metabolic pathway. However, the same pathway was up-regulated in fat tissue after disrupted sleep. Thus, sleep loss may reprogram fat tissue to increase fat storage. Sci. Adv. 10.1126/sciadv.aar8590 (2018).
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