Abstract
The optimal treatment for classic Whipple disease has not yet been determined. A recent study reported encouraging results for initial treatment with intravenous ceftriaxone or meropenem followed by long-term treatment with oral trimethoprim–sulfamethoxazole. However, discrepancies in the failure and/or relapse rates associated with trimethoprim–sulfamethoxazole show that this regimen may not be optimal.
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