Abstract

Meiotic Drive At the core of Mendelian genetics is the concept that gametes are equally likely to carry either of the two parental copies of a gene. Selfish genetic elements can cheat, however, by subverting Mendelian segregation to increase their representation in the gametes. Akera et al. show how the inherent asymmetry of female meiosis is translated to an asymmetry within the spindle machinery that segregates the chromosomes (see the Perspective by McNally). Experiments in mouse eggs revealed how asymmetry is exploited by selfish genetic elements to increase their transmission to the egg. Science , this issue p. [668][1]; see also p. [594][2] [1]: /lookup/doi/10.1126/science.aan0092 [2]: /lookup/doi/10.1126/science.aaq0200

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