How Safe Is Hormone Therapy in Healthy, Recently Menopausal Women?

Abstract

The efficacy of hormone therapy (HT) in managing menopausal symptoms is unquestioned, but controversy about its safety continues. Between 1990 and 1993, investigators for the Danish Osteoporosis Prevention Study randomized 1006 healthy, recently menopausal women (mean age, 49.7), including 196 women who had undergone hysterectomies, to open-label HT or no treatment. In the treatment group, all women received oral estradiol (1–2 mg …