Abstract
How noncrossover homologs are conjoined and segregated in Drosophila male meiosis I: Stable but reversible homolog linkers require a novel Separase target protein.
Highlights
Segregation of chiasmate versus achiasmate bivalentsSegregation of homologous chromosomes is the defining event of meiosis and is central to sexual reproduction
Homologs must establish strong but reversible physical links capable of providing the resistance to poleward spindle forces needed for stable biorientation of homologous centromeres
What form do such linkages take? In the most widespread mechanism, the linkers are chiasmata, in which crossovers between homologous chromatids are anchored by sister chromatid cohesion distal to the crossover [1,2]
Summary
Citation: Adams EE, He Q, McKee BD (2020) How noncrossover homologs are conjoined and segregated in Drosophila male meiosis I: Stable but reversible homolog linkers require a novel Separase target protein. PLoS Genet 16(10): e1008997. https://doi.org/10.1371/journal. pgen.1008997 Funding: Work by the authors cited here was supported by the National Institutes of Health grant #R01 GM040489 to B.D.M. and by funding from the University of Tennessee. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
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