Abstract
BackgroundThe UK Medical Research Council has proposed that complex interventions should be tested in exploratory trials prior to a full-scale trial so as to better define the intervention and test the feasibility of components such as recruitment. It is not clear to what extent this is being done. This study aimed to determine to what extent complex interventions are tested prior to a full-scale trial and whether more or different testing would have led to a different intervention being used in the trial.MethodsEmail survey of the authors of complex intervention trials published in seven major journals in 2004.Results72% (50/69) of eligible authors replied. Eight authors did not consider their interventions to be complex. The majority of respondents' complex interventions were tested (34/42): some extensively. Conversely, only 17 of the 34 published reports describing these trials mention testing. Two-thirds (22/34) of those testing their interventions did not believe that more or different testing would have produced a more effective intervention. 31% (13/42) of all authors did believe further testing would have led to improvements. Five respondents mentioned a lack of funding as a reason for not doing more testing.ConclusionComplex interventions are generally tested prior to their evaluation in a full-scale trial, although the amount of testing varies. Testing is often not described in trial reports, which makes it hard to judge whether a trial result could be improved with a better intervention, or whether further work with a different intervention is required.
Highlights
The UK Medical Research Council has proposed that complex interventions should be tested in exploratory trials prior to a full-scale trial so as to better define the intervention and test the feasibility of components such as recruitment
In 2000 the UK Medical Research Council published a structure for evaluating complex interventions, which proposed that interventions should be modelled and tested prior to a full-scale trial [1]
We wanted to ask the authors of these trial reports whether testing did influence the design of their trials and whether more or different testing would have led to a different intervention being developed
Summary
The UK Medical Research Council has proposed that complex interventions should be tested in exploratory trials prior to a full-scale trial so as to better define the intervention and test the feasibility of components such as recruitment. This study aimed to determine to what extent complex interventions are tested prior to a full-scale trial and whether more or different testing would have led to a different intervention being used in the trial. In 2000 the UK Medical Research Council published a structure for evaluating complex interventions, which proposed that interventions should be modelled and tested prior to a full-scale trial [1]. We wanted to ask the authors of these trial reports whether testing did influence the design of their trials and whether more or different testing would have led to a different intervention being developed. This paper deals with the second of these; the first is covered in a sister paper [4]
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