How Many Are Too Much? Clinical and Epidemiological Considerations for the Era of Poly–Pre- and Postnatal Exposures Relevant for the Developing Brain

Abstract

Empirical evidence from preclinical and epidemiological studies supports the critical role of the early environment for brain development. Against the background of genetic predisposition, environmental conditions thus have the potential to shape risk for mental health disorders (1). These conditions include variation in psychosocial circumstances and stress exposure, parental health and health-related behaviors, nutrition, physical activity, sleep, exposure to environmental chemicals, variation in the geophysical environment, and airborne exposures.