Abstract
We explore with Molecular Dynamics simulations and a statistical model, the ability of carbon nanotubes to be internalized into a model lipid bilayer as a function of their length. The hydrophobicity is one of the key factors responsible for the insertion process. The membrane asymmetry is also needed to drive a complete translocation. Our data demonstrates that shorter nanotubes have a stronger propensity to passively penetrate the bilayer and reach the cytoplasm. Carbon nanotubes excretion appears mostly impossible whatever their length.
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