How ionic conductances shape firing

Abstract

Event Abstract Back to Event How ionic conductances shape firing Susanne Schreiber1* 1 BCCN Berlin, Germany Although for bare spike generation only very few ionic conductances would be needed, neurons express a large variety of ion channels with diverse properties. It can hence be assumed that these conductances fulfil an important role in shaping neural responses. Here we present mechanisms by which ionic conductances can influence two temporal characteristics of the spike code: spike-timing reliability and specific firing patterns. In the first case, we show that a cell’s ion channel composition determines how spike-timing precision depends on the input frequency. In addition, ionic conductances can also modify the extent to which noise affects spike-timing precision. In the second case, we analyse how a resonance in the subthreshold membrane potential, which is known to result from specific ionic conductances with slow dynamics, leads to clustered firing patterns. To fully account for the observed clustered patterns in cells of the entorhinal cortex, however, also spike-induced currents have to be considered. Conference: Bernstein Symposium 2008, Munich, Germany, 8 Oct - 10 Oct, 2008. Presentation Type: Oral Presentation Topic: All Abstracts Citation: Schreiber S (2008). How ionic conductances shape firing. Front. Comput. Neurosci. Conference Abstract: Bernstein Symposium 2008. doi: 10.3389/conf.neuro.10.2008.01.018 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Nov 2008; Published Online: 12 Nov 2008. * Correspondence: Susanne Schreiber, BCCN Berlin, 82152 Planegg-Martinsried, Germany, s.schreiber@biologie.hu-berlin.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Susanne Schreiber Google Susanne Schreiber Google Scholar Susanne Schreiber PubMed Susanne Schreiber Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.