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Abstract
Findings from the 2005 Early Breast Cancer Trialists Collaborative Group overview of the effects of more extensive local therapy on breast cancer survival provide strong evidence supporting a causal link between local-regional cancer control and subsequent breast cancer survival. This article reviews the evidence supporting this link and discusses both the conditions that must be met for improved local-regional therapy to confer a survival benefit and the potential magnitude of the survival benefit from improved local-regional therapy.
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