Abstract
Rhythmic activities such as walking need tight coordination. In mice, pace is tweaked by a specific set of spinal-cord neurons that, surprisingly, make the animals walk faster by inhibiting the underlying circuit. Complex movements such as walking or swimming are produced by networks of nerve cells embedded in the spinal cord. A new study in mice has identified, for the first time, a subset of such nerve cells that controls the speed of locomotion. A unique combination of genetic and electrophysiological techniques reveals how these cells help set the rhythmic activity of spinal cord neurons. This work should be of interest to those studying neurological disorders. Intriguingly the V1 neurons that serve this function are conserved between swimming and walking vertebrates.
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