Abstract
How Does Polymerization Regulate Human Acetyl-CoA Carboxylase 1?
Highlights
Acetyl-CoA carboxylases (ACCs) are biotin-dependent enzymes that catalyze the carboxylation of acetyl-CoA to generate malonyl-CoA, which is used as a two-carbon building block for producing fatty acids and polyketides
ACC1 is found in lipogenic tissues and controls the first and rate-limiting step of de novo fatty acid biosynthesis, while ACC2 is found in muscles and liver and controls the inhibition of fatty acid oxidation in mitochondria
ACCs contain two separate catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT), with biotin linked to biotin carboxyl carrier protein (BCCP)
Summary
Acetyl-CoA carboxylases (ACCs) are biotin-dependent enzymes that catalyze the carboxylation of acetyl-CoA to generate malonyl-CoA, which is used as a two-carbon building block for producing fatty acids and polyketides.1 In humans, ACC1 is found in lipogenic tissues and controls the first and rate-limiting step of de novo fatty acid biosynthesis, while ACC2 is found in muscles and liver and controls the inhibition of fatty acid oxidation in mitochondria. See https://pubs.acs.org/sharingguidelines for options on how to legitimately share published articles.
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