How do the anti-hypertensive drugs influence the relationship between blood pressure and physical activity

Abstract

Essential hypertensive patients have a good relationship between systolic blood pressure (SBP) and physical activity (PA) when treating with calcium channel blockers (CCB), angiotensin converting enzyme inhibitors (ACEI), angiotensin 2 receptor blockers (ARB) and diuretics (D). The aim of this study is to evaluate whether there are the differences in SBP-PA relationship when the patients are treated with different anti-hypertensive drugs. The hypertensive patients treating with CCB (n=32), ACEI (n=23), ARB (n=24) and D (n=13) were participated in this study. The mean age was 58 years in CCB, 60 in ACEI, 58 in ARB and 60 in D. there were no differences in age among the groups. The 24-hour ambulatory blood pressure monitoring (ABPM) system and activetracer for measuring PA were fitted simultaneously to these patients treating with the drugs. The relationship between SBP and PA was analyzed with single regression analysis (y=ax+b). The obtained correlation coefficients (r), “a” and “b” were compared by the analysis of variance (ANOVA). There were no differences in the value of “r” among CCB (0.48), ACEI (0.54), ARB (0.54) and D (0.56). There were no differences in the value of “a” among CCB (0.07), ACEI (0.07), ARB (0.07) and D (0.11). There were no differences in the value of “b” among CCB (133), ACEI (129), ARB (134) and D (132). The hypertensive patients treating with CCB, ACEI, ARB and D have the good relationship between SBP and PA. The values of “r”, “a” and “b” were same regardless of the anti-hypertensive drugs. The anti-hypertensive drugs (CCB, ACEI, ARB and D) reduced blood pressure with the same relationship between systolic blood pressure and physical activity.