Abstract
Amphotericin B (AmB) is a well known polyene antibiotic used to treat systemic fungal infections. It is commonly accepted that the presence of sterols in the membrane is essential for the AmB biological activity, i.e, for the formation of transmembrane ion channels. The selective toxicity of AmB for fungal cells is attributed to the fact that it is more potent against fungal cell membranes containing ergosterol than against the mammalian membranes with cholesterol. According to the ‘primary complex’ hypothesis, AmB associates with sterols in a membrane to form binary complexes which may subsequently assemble into a barrel-stave channel.
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