How Decreased Level of Plasma Tryptophan Play Role in Diabetic Patients?

Abstract

Tryptophan is an essential amino acid found in many protein-based foods and dietary proteins including meats, dairy, fruits, and seeds. High-glycaemic index and -glycaemic load meals also increase the availability of tryptophan. The main objective of the study is to find the role of tryptophan in diabetic patients. Tryptophan metabolism has been reported highly associated with insulin resistance and diabetes risk. The activity of rate-limiting enzyme of tryptophan-kynurenine, indoleamine-2,3-dioxygenase (IDO), was enhanced significantly in T2D patients, thus downstream metabolites such as kynurenine, kynurenic acid, xanthurenic acid and hydroxykynurenine, were higher in T2D than in non-diabetic subjects, although inconsistent observations of tryptophan levels. Returning to the question posed at the beginning of the review, these studies have shown that decreased level of tryptophan plays an important role in diabetic patients. decrease in plasma TRP levels in diabetic patients regardless of their gender and these patients also exhibited a greater incidence of memory dysfunction compared to the controls.