Abstract
Objectives: The aim of this study was to evaluate how can we predict success in poor responder patients in terms of pregnancy rate and live birth rate. Material and method: This study is a review of the newest papers that have in the center the poor responders undergoing treatment involving assisted reproductive techniques (ART). Outcomes: The results show that the most reliable factors when counseling a poor responder patient are age and Anti-Müllerian hormone (AMH) level. Conclusions: The most important factors that influence pregnancy rate are age and ovarian reserve, but other factors such as male pathology and laboratory techniques must be studied deeper.
Highlights
Anti-Müllerian hormone (AMH) has become the main marker for the evaluation of the ovarian reserve
AMH and antral follicle count (AFC) are important means of predicting the chances of success, but there are other variables that should not be neglected and that play a major role in the end result, namely: age, sperm quality, genetic quality of embryos, stimulation protocols, laboratory procedures and techniques, embryo transfer technique[6,37,38]
Giving that fertility naturally decreases with age in both natural and ovarian-stimulated cycles, the decline starting around the age of 30 with a steeper slope after 35 years, and that nowadays women tend to delay procreation due to the prioritization of their career and financial status consolidation, assisted reproductive techniques (ART) are more and more used and infertility specialists try more often to bend the natural boundaries of fertility
Summary
One of the most frequently addressed questions to the infertility specialist, before a couple decides to use in vitro fertilization (IVF) to conceive, is: “What are the odds of getting pregnant through IVF?”. Most graphs consider the most important parameters in assessing the chances of obtaining through IVF a pregnancy finalized with an alive newborn, namely: age and ovarian reserve[1]. The birth rate has increased among women over the age of 30 and up to 44 years. More recent studies show that the measure of success is given by the number of euploid blastocysts we can obtain. At the age of 28, 3 blastocysts are needed to have a 90% chance that one of them will be euploid[5]. A 2021 study shows that for a 95% pregnancy rate, 3 euploid blastocysts are needed, independent of the age of the mother[6]. But the number of euploid blastocysts we can get from a full IVF cycle is age-dependent, as many studies show.
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