Abstract
Trust in scientific research is diminished by evidence that data are being manipulated. Outcome switching, data dredging and selective publication are some of the problems that undermine the integrity of published research. Methods for using blockchain to provide proof of pre-specified endpoints in clinical trial protocols were first reported by Carlisle.We wished to empirically test such an approach using a clinical trial protocol where outcome switching has previously been reported. Here we confirm the use of blockchain as a low cost, independently verifiable method to audit and confirm the reliability of scientific studies.
Highlights
Trust in scientific research is diminished by evidence that data are being manipulated[1]
Data dredging and selective publication are some of the problems that undermine the integrity of published research
Despite the creation of numerous trial registries problems such as differences between pre-specified and reported outcomes persist[3,4,5]. If readers this a new account was created in Strongcoin©9 and the SHA256 digest used as the account password to generate a private key[6]
Summary
Trust in scientific research is diminished by evidence that data are being manipulated[1]. Despite the creation of numerous trial registries problems such as differences between pre-specified and reported outcomes persist[3,4,5]. If readers this a new account was created in Strongcoin©9 and the SHA256 digest used as the account password to generate a private key[6]. The protocol document was edited to reflect any changes to pre-specified outcomes as reported by the COMPare group[3] This was used to create a further SHA256 digest which differed to that for the pre-specified protocol and would not allow the private key to be unlocked in Strongcoin©3
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