Abstract
Background: Endoscopic treatment of high-grade dysplasia (HGD) or intramucosal cancer (IMC) in Barrett's esophagus (BE) is a valid alternative to surgery. Submucosal cancer (SMC), however, has a high risk of lymphatic involvement and should be treated surgically. Many centers treat early BE neoplasia by endoscopic resection (ER) of the most involved area followed by ablation therapy (AT) of the remaining BE. Proper endoscopic work-up is of crucial importance here: SMCs that are not resected but ablated will be missed since AT lacks histological correlation.
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