Abstract
EVIDENCE-BASED ANSWER In patients with clinical findings consistent with rheumatoid arthritis (RA), a C-reactive protein (CRP) level of more than 0.06 mg/dL is modestly useful for ruling in, but is not useful for ruling out RA when obtained within 3 and 24 months of symptoms onset (SOR: B, prospective cohort study). CRP measurements in the years prior to diagnosis of RA do not accurately predict progression to RA (SOR: B, prospective cohort study). Elevated CRP is more sensitive but less specific than rheumatoid factor, anti-cyclic citrullinated protein (anti-CCP), and erythrocyte sedimentation rate (ESR) for the diagnosis of RA (SOR: B, cross-sectional survey).
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