Abstract

Structural Biology Hydrogen-metabolizing organisms use an [NiFe]-hydrogenase to catalyze hydrogen oxidation. One type of [NiFe]-hydrogenase, the NAD+-reducing soluble [NiFe]-hydrogenase (SH), couples reduction of NAD+ to the oxidation of hydrogen. Shomura et al. solved the structure of SH from an H2-oxidizing bacterium in both the air-oxidized and the active reduced state. In the reduced state, the NiFe catalytic center in SH has the same ligand coordination as in other [NiFe]-hydrogenases. However, the air-oxidized active site has an unusual coordination geometry that would prevent O2 from accessing the site and so may protect against irreversible oxidation. Science , this issue p. [928][1] [1]: /lookup/doi/10.1126/science.aan4497

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