Abstract
Assembly of a bipolar mitotic spindle is critical for equal partitioning of the genetic material into daughter cells during mitosis. In normal cells, each of the two spindle poles is organized by one centrosome. In many cancer cells, however, there are extra centrosomes, which are often clustered to enable bipolar spindle assembly. This provides an important mechanism for cancer cells to escape fatal multipolar divisions and accumulate genomic heterogeneity through chromosome mis-segregation. To dissect how a cell achieves bipolar spindle assembly with different centrosome numbers, we developed a biophysical model for centrosome movement during spindle assembly.
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