Abstract
Process control, breath analysis for medical purpose or the investigation of biological samples are new applications of ion mobility spectrometry or differential mobility spectrometry coupled with rapid gas-chromatographic pre-separation. Especially if pre-concentration steps should be avoided, they require a realistic and flexible multi-compound calibration down to the pptV range including relative humidity values up to 100% for identification of analytes using mobility and retention time as well as for their quantification using the signal intensity as a measure. With HovaCAL® 3834SP-VOC, a novel calibration gas generator is presented that fulfils those requirements. The performance of HovaCAL® was validated for various compounds and mixtures with varying humidity comparing 3 particular equipments. Excellent results have been obtained with standard deviations of the provided concentrations of <8% and of <0.7% for the relative humidity range of 0–100%. Furthermore, standard deviation of the provided concentrations was <3% for varying experimental conditions. The long term stability of the provided concentrations for different instrumental parameters was proofed, standard deviations of <3% have been obtained. HovaCAL® enables for the first time a reliable calibration with complex humid mixtures down to the pptV range and—compared to permeation sources—a flexible and rapid change of compounds.
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More From: International Journal for Ion Mobility Spectrometry
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