House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population

Mee Kyoung Kim,Jee Sun Jeong,Kyungdo Han,Ki-Ho Song,Hyuk-Sang Kwon,Ki Hyun Baek

doi:10.1038/s41598-018-20573-0

Mee Kyoung Kim, Jee Sun Jeong + Show 4 more

Open Access

https://doi.org/10.1038/s41598-018-20573-0

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Journal: Scientific Reports	Publication Date: Feb 8, 2018
Citations: 5	License type: open-access

Affiliation: Catholic University of Korea

Abstract

Immunoglobulin E (IgE) is known to activate mast cells. Prior studies have shown that mast cells contribute to diet-induced obesity and diabetes mellitus (DM). We aimed to determine whether adults with IgE sensitization were at risk of DM. We performed assays regarding serum total IgE and allergen-specific IgE levels against the house dust mite, the cockroach, and the dog on 1,528 adults randomly sampled from every age and gender group in various districts. The total and three allergen-specific IgE levels were positively correlated with fasting glucose level and insulin resistance. Subjects with increased levels of total IgE (>100 kU/L), compared to those without, had an odds ratio (OR) of 1.72 (95% confidence interval [95% CI], 1.17–2.54) for DM after adjusting for various covariates. Further controlling for previous allergic disease did not attenuate the association between total IgE level and DM. Subjects sensitized to the house dust mite (OR 1.63, 95% CI, 1.03–2.59) and the cockroach (OR 2.27, 95% CI, 1.40–3.66) were also at increased risk of DM. We found a strong positive association between IgE sensitization and DM in a general Korean population, suggesting that IgE may be an important independent risk factor for metabolic diseases in Koreans.

Highlights

Prior studies have shown that mast cells contribute to diet-induced obesity and diabetes mellitus (DM)[1,2]
The cross-sectional analyses included data on 1,528 adults (755 males and 733 females) with a mean age of 49 years; 153 (10%) had DM, and this group was more likely than others to be older, male, and obese and to have a lower income, an educational level less than high school and higher white blood cell (WBC) counts (Table 1)
The total Immunoglobulin E (IgE) level was negatively correlated with the HDL cholesterol level (r = –0.067, P = 0.034)

Summary

Introduction

Prior studies have shown that mast cells contribute to diet-induced obesity and diabetes mellitus (DM)[1,2]. Inflammatory mediators released by mast cells increase capillary permeability and trigger vasoconstriction and endothelial cell remodeling in patients with atherosclerosis[3,4,5]. These mediators increase cytokine-induced insulin resistance (IR) and impair insulin secretion[2]. Mast cells participate directly in the development of diet-induced obesity and diabetes, and mast cell inhibitors offer hope to patients with these common, chronic inflammatory conditions[1]. We examined the relationship between IgE sensitization and metabolic syndrome (insulin resistance syndrome)

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