Abstract

Neonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries. Non-invasive methods for early detection and treatment of hyperbilirubinemia are urgently needed. In this study, we used transcutaneous bilirubin (TcB) measurements to develop an hour-specific TcB nomogram for the effective management of hyperbilirubinemia in Myanmar newborns. The bilirubin levels of neonates born in Central Women Hospital in Yangon, Myanmar were measured three times a day within 72h after birth using a transcutaneous bilirubinometer. An hour-specific TcB nomogram was created based on the data. Participants were 512 infants (287 boys, 225 girls) born in Central Women's Hospital in Yangon. The mean (±SD) gestational age was 38.4±1.2weeks; birthweight was 3078±412g. A total of 3,039 plots were obtained, and the TcB nomogram was created with smoothed percentile curves (97.5th, 50th, and 2.5th percentiles) for 0-72h after birth. An hour-specific TcB nomogram was successfully created to manage hyperbilirubinemia in Myanmar newborns.

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